The sixth house, like the sixth sign Virgo, represents the last personal stage in development, and is thus a critical one. The self-adjustment we undergo here determines our ability to relate to others on an equal footing (seventh house), and, by its success or failure, unites us with or separates us from others. This is the house of work and health or the lack of either, hygiene and nutrition, service, servants and servitude, daily routine, employment by others, and small animals and pets. Whereas fifth house activities are done for their own sake, sixth house work is done out of necessity or in support of other, more self-expressive activities. When our work becomes an end in itself, however, or we lose track of its purpose, it becomes pointless, and the result can be physical or psychological illness. The issue with planets in the sixth house is to remember what the purpose of our work is, where is it’s joy? Without this knowledge, life isn’t worth living.

Astronomically speaking, the sixth house is that one-twelfth sector of the local sky just below the western horizon (see above picture) occupied by planets in the two hours after they set.

With Uranus in your sixth house you tend to be high strung and nervous. Chronic health problems can be the result of not addressing your irritation and impatience. You either find the steady routine of one job unbearable, or drive yourself mercilessly far beyond your limits. Your unconventional approach to working may require a special situation for you, such as a job that gives you a lot of movement and freedom. Or your work situation may be so creative and unconventional that you have that freedom internally. If you work for someone else you're going to have to learn to do what you're told. If you're the boss, you may have a tendency towards bruskness or a lack of sympathy, causing problems with your employees until this is recognized and dealt with.

If Uranus is within 10° of the descendant (seventh house cusp), then it is conjunct the descendant and much of the foregoing interpretation starts to become weaker. If Uranus is in the sixth house AND within 4° or 5° of the descendant, then it is said to be on the "dark side" of the seventh house, and its influence will be felt in the seventh as well as in the sixth house. The closer a sixth house Uranus is to the descendant, the more it will be interpreted as though it were in the seventh house; when less than 3° from the descendant, a sixth house Uranus expresses itself primarily— and eventually entirely— in the seventh house.