The mutable signs—Gemini (mutable air), Virgo (mutable earth), Sagittarius (mutable fire), and Pisces (mutable water)—are the final sign of each season, preparing the way for the next. They are flexible, versatile, harmonizing, adaptable, good with people, highly personal and good imitators. Too many mutable signs in a horoscope, on the other hand, can indicate a lack of focus and will, and a propensity to negativity. Such individuals are very changeable and hard to pin down, like "the rolling stone that gathers no moss." Lacking the strength, will and persistence conferred by fixed signs, or the assertiveness of cardinal signs, the individual with too many mutable signs may allow external circumstances to control his or her life.

Of the three quadruplicities, difficult aspects in the mutable signs are the easiest to overcome. They symbolize problems that are just beginning to manifest in this life, and can be handled by the correct mental attitude.